Research indicates that social isolation and loneliness have a negative effect on health and wellbeing among older people. Various technology-based interventions have been offered to reduce social isolation; however, research demonstrating the role of various types of technologies and their effectiveness in dealing with social isolation among seniors is scarce. This study undertakes a systematic literature review of empirical studies on various types of technologies and their effectiveness in alleviating social isolation among seniors. Relevant electronic databases were searched and through 6886 initial set of studies published from 2000 to 2015 we have found eight different technologies that have been applied to alleviate social isolation, namely, general ICT, video game, robotics, personal reminder information and social management system, asynchronous peer support chat room, social network sites, Telecare and 3D virtual environment. We further evaluated the effectiveness of the technologies with social isolation among seniors. Findings show that technologies can be used to reduce social isolation among seniors. However, more studies are needed to evaluate the effectiveness of new technologies.