With the increasing market share of Mac OS X operating system, there is a corresponding increase in the number of malicious programs (malware) designed to exploit vulnerabilities on Mac OS X platforms. However, existing manual and heuristic OS X malware detection techniques are not capable of coping with such a high rate of malware. While machine learning techniques offer promising results in automated detection of Windows and Android malware, there have been limited efforts in extending them to OS X malware detection. In this paper, we propose a supervised machine learning model. The model applies kernel base SupportVector Machine and a novel weighting measure based on application library calls to detect OS Xmalware. For training and evaluating the model, a dataset with a combination of 152 malware and 450 benign were created. Using common supervised Machine Learning algorithm on the dataset, we obtain over 91% detection accuracy with 3.9% false alarm rate. We also utilize Synthetic Minority Over-sampling Technique (SMOTE) to create three synthetic datasetswith different distributions based on the refined version of collected dataset to investigate impact of different sample sizes on accuracy of malware detection. Using SMOTE datasets we could achieve over 96% detection accuracy and false alarm of less than 4%. Allmalware classification experiments are tested using cross validation technique. Our results reflect that increasing sample size in synthetic datasets has direct positive effect on detection accuracy while increases false alarm rate in compare to the original dataset.