High Performance Work System (HPWS) becomes highly important as a source of competitive advantage in today’s business environment. Researches have indicated that HPWS able to enhance the organization and employee performance. This research extends the literature to identify the relationship between HPWS and organization performance with the mediating role of employee attitude. The mediating elements are employee empowerment and organizational commitment. The focus of the research is on the human resource practices as the components of the HPWS towards departmental performance among the public universities in Malaysia. The data collection method utilized self-administered questionnaires based upon the fundamental constructs proposed in the conceptual model. Data for this study was collected through a survey distributed randomly among the lecturers of the Business School from two Research Universities in Malaysia. Findings demonstrate that employee involvement and organizational learning inspire employees to have a positive empowerment and organizational commitment. Thus, this concluded that the mediating roles of employee empowerment and organizational commitment influence HPWS to boost organizational performance.